In un forum che tratta di salute e malattie, può succedere che improvvisamente qualcuno offra la soluzione tanto agognata, via mail o via messaggio privato.
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conferma le propieta' antiaggreganti anche....
''In effetti la possibile azione antiossidante della melatonina sulle LDL e sulle cellule endoteliali, cosi come le proprietà antiaggreganti dimostrate in vitro, potrebbero ridurre il rischio di aterosclerosi. Inoltre la melatonina sembra influenzare in maniera importante anche l’emodinamica circolatoria aumentando il flusso sanguigno nei vasi carotidei, riducendo i livelli circolanti di noradrenalina.''
eppure la melatonina ha fermato le emoraggie intestinali da piastrinopenia
E’ stato pubblicato dalla nota rivista scientifica statunitense Journal of Pineal Research, l’articolo: “Melatonin makes splenectomy unnecessary in two patients with idiopathic thrombocytopenic purpura refractory to corticosteroids”. In questo lavoro il dottor Todisco descrive come la cura a base di melatonina abbia evitato la splenectomia a due pazienti piastrinopenici già indirizzati a questo intervento per la loro refrattarietà ai corticosteroidi.”
Abstract: Although melatonin treatment following trauma-hemorrhage or ischemic reperfusion prevents organs from dysfunction and injury, the precise mechanism remains unknown. This study tested whether melatonin prevents liver injury following trauma-hemorrhage involved the protein kinase B (Akt)-dependent heme oxygenase (HO)-1 pathway. After a 5-cm midline laparotomy, male rats underwent hemorrhagic shock (mean blood pressure approximately 40 mmHg for 90 min) followed by fluid resuscitation. At the onset of resuscitation, rats were treated with vehicle, melatonin (2 mg/kg), or melatonin plus phosphoinositide 3-kinase (PI3K) inhibitor wortmannin (1 mg/kg). At 2 hr after trauma-hemorrhage, the liver tissue myeloperoxidase activity, malondialdehyde, adenosine triphosphate, serum alanine aminotransferase, and aspartate aminotransferase levels were significantly increased compared with sham-operated control. Trauma-hemorrhage resulted in a significant decrease in the Akt activation in comparison with the shams (relative density, 0.526 ± 0.031 versus 1.012 ± 0.066). Administration of melatonin following trauma-hemorrhage normalized liver Akt phosphorylation (0.993 ± 0.061), further increased mammalian target of rapamycin (mTOR) activation (5.263 ± 0.338 versus 2.556 ± 0.225) and HO-1 expression (5.285 ± 0.325 versus 2.546 ± 0.262), and reduced cleaved caspase-3 levels (2.155 ± 0.297 versus 5.166 ± 0.309). Coadministration of wortmannin abolished the melatonin-mediated attenuation of the shock-induced liver injury markers. Our results collectively suggest that melatonin prevents hemorrhagic shock-induced liver injury in rats through an Akt-dependent HO-1 pathway.
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